Pain Killer drug Amethocaine Powder Tetracaine HCL for Local anesthetics

ocal Anesthetic Drugs Pain Killer Powder Tetracaine HCl

Product Nametetracaine hydrochloride
AliasTetracaine HCl; 2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS Registry Number136-47-0
Einecs No205-248-5
Molecular FormulaC15H25ClN2O2
Molecular Weight300.8242
Flash Point189.3°C
Appearancewhite powder
Boiliing Point389.4°C at 760 mmHg
Vapor Pressure2.87E-06mmHg at 25°C



COA

Test ItemsSpecificationTest Results
AppearanceFine, white, crystalline, odorless powderconfirm
IdentificationABC in Passconfirm
SolubilityVery soluble in water, soluble in Alcohol; insoluble in Ether and Benzeneconfirm
USP Reference standardsUSP Tetracaine Hydrochloride RS. USP Endotoxin RS.confirm
Melting point145~150 degree146.0~147.5
degree
Chromatographic purityIn Passconfirm
Related substanceNot more than the reference solution 0.05%confirm
Heavy metals≤10ppmconfirm
PH4.5-6.55.8
Residue on ignition≤0.10%0.05%
Loss on Drying≤ 0.5%0.19%
Assay98.0 -101.0%100.1%
ConclusionConfirms USP 32


product description

Tetracaine HCL chloride is synthesized from 4-butylaminobenzoic acid. The esterification reaction is carried out by acid catalysis to form ethyl ester. The base-catalyzed transesterification is achieved by boiling ethyl 4-butylaminobenzoic acid with an excess of 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Tetracaine HCL (INN, also known as tetracaine; trade names Pontocaine.Ametop and Dicaine) are potent topical anesthetics of the ester groups. It is mainly used for ophthalmology and antipruritic agents and has been used for spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of the calcium release pathway (Lannottine receptor), which controls the release of calcium in intracellular stores. Dicaine is an allosteric blocker for channel function. At low concentrations, tetracaine causes initial inhibition of spontaneous calcium release events, whereas at high concentrations, tetracaine is completely released.

Product Application

A for block anesthesia and epidural anesthesia.
B- is also used for myocardial infarction, digital, glucose metabolism poisoning, surgery and other ventricular arrhythmias. Such as ventricular tachycardia, ventricular premature beats, ventricular fibrillation.
C as an analgesic for drug injection.
D is also used in suppositories and ointment preparations

The efficacy of tetracaine hydrochloride

Tetrahydrate hydrochloride used in the production of spinal anesthesia for two to three hours of the program. Parenteral administration of tetramine hydrochloride stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby performing local anesthesia.

The effect began very fast, prolonged duration (surgical anesthesia for two or three hours or more). Hydrochloride tetracaine detoxifies aminobenzoic acid and diethylaminoethanol by plasma esterase.

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